Diluting 5-fluorouracil with normal saline reduces patient discomfort

  • Keith Ong
  • Ru Ming Ong
  • Daisy Shu
Keywords: 5-Fluorouracil (5-FU), normal saline, trabeculectomy


5-Fluorouracil (5-FU) is an antimetabolite and is used to improve the success rate of trabeculectomies by inhibition of subconjunctival fibrosis. It can be administered postoperatively as a subconjunctival injection or given intraoperatively via cellulose sponge soaked in 5-FU and placed between the sclera and conjunctival flap. The advantage of injecting 5-FU subconjunctivally postoperatively is that the dose and frequency can be titrated according to patients’ needs. Subconjunctival injection may be uncomfortable and this could be due to the alkaline nature of 5-FU (pH 9.20) and its osmolarity of 384 mmol/l. It would be beneficial if this discomfort can be minimised as the injection may need to be given several times.


How to Cite
Ong, K., Ong, R., & Shu, D. (2019). Diluting 5-fluorouracil with normal saline reduces patient discomfort. Asian Journal of Ophthalmology, 16(4), 229-230. https://doi.org/10.35119/asjoo.v16i4.573
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