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This work is licensed under a Creative Commons Attribution 4.0 International License.
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© Asian Journal of Ophthalmology, 2018
Affiliations
Kah Lay Oh
Universiti Kebangsaan Malaysia Medical Centre
Aida Zahidin
Universiti Kebangsaan Malaysia Medical Centre
Umi Kalthum Md Noh
Universiti Kebangsaan Malaysia Medical Centre
Safinaz Mohd Khialdin
Universiti Kebangsaan Malaysia Medical Centre
Ghee Chien Ooi
Cryocord Sdn. Bhd.
Kong Yong Then
International Specialist Eye Centre
How to Cite
Case series of cultivated oral mucosa epithelium transplantation for limbal stem cell failure
experience in Malaysia
- Kah Lay Oh ,
- Aida Zahidin ,
- Umi Kalthum Md Noh ,
- Safinaz Mohd Khialdin ,
- Ghee Chien Ooi ,
- Kong Yong Then
Vol 16 No 2 (2018): Asian Journal of Ophthalmology
Submitted: Aug 2, 2016
Published: Nov 21, 2018
Abstract
Purpose: To report a case series of seven eyes (six patients) with severe limbal stem cell failure who underwent cultivated oral mucosa epithelium transplantation (COMET) in preparation for corneal transplant surgery and assess the change in visual acuity postoperatively.
Design: Case series.
Methods: A retrospective analysis of an interventional case series of six patients with severe limbal stem cell deficiency who underwent COMET between 2012 and 2015 was performed. Six eyes had COMET followed by corneal transplant, and one eye had corneal transplant preceding COMET. The change in the visual acuity after operation was evaluated.
Results: A total of six patients with seven eyes were studied. All of them had severe ocular surface disease with limbal stem cell deficiency (LSCD) secondary to chemical injury (five eyes), SJS (one eye), and severe ocular rosacea (one eye). Four eyes had improvements in visual acuity, two of which achieved best corrected visual acuity (BCVA) of 6/12.
Conclusion: The use of COMET helps to optimize the ocular surface in severe LSCD for further corneal transplant surgeries. It has helped to improve the graft uptake and subsequent visual improvement, especially in chronic chemical burn cases.