Central Corneal Thickness in Congenital Aniridia and its Role in Glaucoma in an Indian Population
Aim: To determine the range and distribution of central corneal thickness in patients with aniridia and compare with age- and sex-matched controls.
Methods: This was a prospective cross-sectional observational case-control study performed at a tertiary eyecare hospital. All patients diagnosed with aniridia from June 2006 to April 2008 were enrolled. Patients were excluded if they had corneal oedema, central corneal scars, central aniridic keratopathy, or any history or signs suggestive of previous surgery or injury. Central corneal thickness was measured by ultrasound
pachymetry and the mean of 5 measurements per eye was used as the study measurement. The results were compared with those of age- and sex-matched controls.
Results: The mean central corneal thickness in the aniridia group was 0.603 mm compared with 0.566 mm in the control group (p = 0.0083).
Conclusions: This study has determined the range and distribution of CCT in Indian patients with aniridia and substantiates the fact that patients with aniridia in an Indian cohort also have significantly thicker corneas. This needs to be considered for making accurate IOP measurements in these patients to ascertain the appropriate management.