Pattern ERG as a predictor in ocular hypertensive

  • Paaraj Dave Dr. Thakorbhai V Patel Eye Institute
  • Jitendra Jethani Baroda Children eye care and squint Clinic
Keywords: Pattern Electroretinogram, PERG, Repeatability, Glaucoma, Ocular Hypertension


Purpose: To report the repeatability of Pattern Electrotretinogram (PERG) and its findings in ocular hypertension (OHT) and normal eyes.

Methods: A cross-sectional study where PERG responses were compared between the study group comprising of 80 eyes of 80 patients with intraocular pressure (IOP)>21 mmHg and the control group with 80 eyes of 80 normal individuals (IOP≤21mmHg). The optic disc and the visual fields were normal with a visual acuity of ≥ 0.8 in both groups. PERG was recorded twice for each individual in the control group by a single operator on 2 consecutive days to assess the repeatability.

Results: The mean age in the study and control groups was 50.05±10.03 and 54.8±7.66 years

(p=0.44) respectively. The mean IOP was 26.55±3.9 mmHg for the study group as opposed to 14.45±2.9 mmHg for the controls (p<0.001). The central corneal thickness and the cup-disc ratio was similar between the groups (p>.05). The P50-N95 amplitude (p=0.01) and the P50 latency (p<0.001) was statistically significantly different between both the groups. The intra-class correlation coefficient (ICC) showed poor agreement for all parameters except for N35-P50 0.8 to 16 degree check size amplitude ratio (PERG ratio).

Conclusion:  Increase in P50 latency emerges as a new candidate for early glaucoma indicator in addition to reduction in P50-N95 amplitude. PERG parameters suffer from high test-retest variability. Deterioration in PERG recordings should be interpreted with caution. The variability is lesser for the PERG ratio which maybe more meaningful while monitoring for change over time.

Author Biography

Jitendra Jethani, Baroda Children eye care and squint Clinic
Pedaitric Ophthalmologist and Squint Specialist
How to Cite
Dave, P., & Jethani, J. (2016). Pattern ERG as a predictor in ocular hypertensive. Asian Journal of Ophthalmology, 15(2).
Original Articles