Rare orbital malignancies in xeroderma pigmentosum – a case series and review of literature

  • Syed Ali Raza Rizvi Institute of Ophthalmology, Jawaharlal Nehru Medical College, AMU, Aligarh -UP
  • Faraz Yusuf Institute of Ophthalmology, Jawaharlal Nehru Medical College, AMU, Aligarh -UP
  • A K Amitava Institute of Ophthalmology, Jawaharlal Nehru Medical College, AMU, Aligarh -UP
  • S H Arif Department of Pathology, Jawaharlal Nehru Medical College, AMU, Aligarh -UP
  • M Vasenwala Department of Pathology, Jawaharlal Nehru Medical College, AMU, Aligarh -UP
  • Ghazala Mehdi Institute of Ophthalmology, Jawaharlal Nehru Medical College, AMU, Aligarh -UP
DOI: https://doi.org/10.35119/asjoo.v13i3.133
Keywords: Xeroderma pigmentosum, orbital malignancy, amelanotic melanoma, sebaceous gland carcinoma

Abstract

Xeroderma pigmentosum (XP) is a rare genodermatosis, with a defect affecting recovery of ultraviolet-induced damages and characterized by a high rate of malignancies of the exposed skin areas. Inheritance is autosomal recessive and consanguinity of parents is common. We report two siblings with a history of consanguinity having XP with rare orbital malignancies. The first case had orbital amelanotic melanoma and the second case had sebaceous gland carcinoma (SGC) with orbital extension. In this case series, we have discussed and reviewed orbital malignancies in XP with respect to this report and other cases in the literature. Although early detection and treatment of these malignancies will reduce morbidity and mortality, genetic counselling remains the most important protective measures for XP.

Published
2014-04-01
How to Cite
Raza Rizvi, S., Yusuf, F., Amitava, A., Arif, S., Vasenwala, M., & Mehdi, G. (2014). Rare orbital malignancies in xeroderma pigmentosum – a case series and review of literature. Asian Journal of Ophthalmology, 13(3), 106-110. https://doi.org/10.35119/asjoo.v13i3.133
Issue
Vol 13 No 3 (2014)
Section
Case Reports/Case Series

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication, with the work twelve (12) months after publication simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).